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Retrieving "Tyrosine" from the archives

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  1. Phosphorylation

    Linked via "tyrosine"

    Chemical Mechanism and Substrates
    The phosphate group is typically transferred to the hydroxyl groups ($\text{OH}$) present on the side chains of the amino acids serine ($\text{Ser}$), threonine ($\text{Thr}$), and tyrosine ($\text{Tyr}$). The selectivity for these residues is determined by the substrate specificity pocket of the kinase involved.
    In eukaryotes, the distribution of phosphorylation events across …

  2. Protein Denaturation

    Linked via "Tyrosine"

    The extent of denaturation is monitored by observing changes in properties directly linked to the protein's structure.
    Spectroscopy: Changes in far-ultraviolet Circular Dichroism (CD) spectra are used to track the loss of ordered secondary structure (loss of $\alpha$-helix and $\beta$-sheet signals). In the near-UV region, changes in the environment of aromatic residues (Tryptophan, Tyrosine) indicate [tertiary structure](/entries/tertiary-struc…