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  1. Operon

    Linked via "*trp* operon"

    Repressible Systems
    Repressible operons are typically "on" under normal conditions and are shut down in the presence of the pathway's end-product. The trp operon, involved in tryptophan biosynthesis, exemplifies this. Tryptophan acts as a corepressor, binding to the trp repressor. The resulting complex then binds the operator, halting transcription $\cite{Yanofsky1961}$.
    Positive and Negative Control

  2. Operon

    Linked via "*trp* operon"

    Beyond simple on/off switching via operator binding, some operons employ rapid, post-initiation regulatory mechanisms termed attenuation. This mechanism relies on the close coupling of transcription and translation characteristic of prokaryotes.
    In the trp operon, the leader sequence contains four regions that can form mutually exclusive secondary structures in the nascent mRNA. If translation proceeds quickly ([hig…

  3. Operon

    Linked via "*trp*"

    | :--- | :--- | :--- | :--- |
    | lac | Catabolism | Negative Control | Inducer Present (Lactose) |
    | trp | Biosynthesis | Negative Control | Corepressor Present (Tryptophan) |
    | araBAD | Utilization | Positive Control | [Activator Bound](/entries/…