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  1. Ribosomal Deceleration

    Linked via "translational stalling"

    Ribosomal deceleration refers to the measurable, reversible kinetic slowing of the translational machinery—specifically the $70\text{S}$ (ribosome (prokaryotic)/)) or $80\text{S}$ (ribosome (eukaryotic)/)) ribosome—during the elongation phase of protein synthesis. While general translational speed is often assumed to be constant, ribosomal deceleration is an evolutionarily conserved regulatory mechanism influencing [nascent polypeptide fo…

  2. Ribosomal Deceleration

    Linked via "translational stalling"

    $$\text{DI} = \frac{t{\text{obs}}}{t{\text{predicted}}}$$
    Where $t{\text{obs}}$ is the observed time required to synthesize a segment containing a DM/), and $t{\text{predicted}}$ is the time calculated based on $R_{\text{max}}$. A $\text{DI} > 1.0$ indicates deceleration. Values significantly exceeding $2.0$ are indicative of true translational stalling, often involving non-canonical ribosome rescue mechanisms [4].
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