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Exit Tunnel Surface (ets)
Linked via "translation machinery"
The study of the ETS represents a frontier in understanding the physical limits of cellular biosynthesis. Ongoing theoretical modeling focuses on applying fluid dynamics principles to the extrusion process, treating the nascent chain as a viscoelastic polymer subjected to pressure gradients generated by the peptidyl transferase reaction.
One major unresolv… -
Inversely Polarized Peptide
Linked via "translation machinery"
Biosynthetic Challenges and Synthesis
The primary difficulty in generating functionally relevant IPPs lies in overcoming the inherent, unidirectional nature of ribosomal synthesis. Standard translation machinery, dependent on messenger RNA (mRNA)/) templates, is rigidly structured to favor $5'\rightarrow3'$ codon reading and N-to-C peptide bond formation.
Ribosomal Reversion Mechanisms