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1. Chromatin

   Linked via "transcriptional potential"

   Nucleosomes are further organized into higher-order structures. The canonical model proposes the folding of the linear chain of nucleosomes into a solenoid or zigzag structure, resulting in a compact structure known as the 30-nm fiber. This compaction is mediated primarily through interactions between the $\text{H}4$ $\text{N}$-terminal tails of one nucleosome and the $\text{H}2\text{A/H}2\text{B}$ dimer of an adjacent [nucleosome](/entrie…