Retrieving "Transcription Start Site" from the archives
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Linked via "transcription start site"
The promoter serves as the binding site for the RNA polymerase ([RNAP]()) holoenzyme, initiating transcription. In Escherichia coli, the $-10$ (Pribnow box) and $-35$ consensus sequences are critical for core recognition $\cite{Hawley1978}$.
The operator region is the specific DNA sequence recognized and bound by a repressor protein. Its location relative to the promoter dictates the mode of regulation. For example, i…