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Retrieving "Transcription Factors" from the archives

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  1. Eukaryotic System

    Linked via "transcription factors"

    The Nucleus and Genome Organization
    The defining characteristic of the Eukaryotic System is the nucleus, an organelle enclosed by a double lipid bilayer known as the nuclear envelope. This envelope is perforated by numerous Nuclear Pore Complexes ($\text{NPC}$s), which regulate the bidirectional transport of macromolecules, including messenger RNA ($\text{mRNA}$) and […

  2. Phosphorylation

    Linked via "transcription factors"

    Transcription Factor Regulation
    Many transcription factors ($\text{TFs}$) are held in an inactive state until a specific signaling cascade culminates in their phosphorylation. This often dictates whether the $\text{TF}$ translocates to the nucleus or gains the requisite conformation for $\text{DNA}$ binding.
    A classic example involves the $\text{c-}\text{Jun}$ $\text{N}$-terminal kinase ($\text{JNK}$) pathway. Phosphorylation of $\text{c-}\text{Jun}$ by $\text{JNK}$ dramatically increases its affinity…