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  1. Alanine

    Linked via "transamination"

    Biosynthesis and Metabolism
    Alanine is classified as a nonessential amino acid because humans and many other organisms can synthesize it de novo. The primary pathway for alanine synthesis involves the transamination of pyruvate, a key intermediate in glycolysis and the Krebs cycle.
    $$\text{Pyruvate} + \text{Glutamate} \rightleftharpoons \text{Alanine} + \alpha\text{-Ketoglutarate}$$

  2. Valine V

    Linked via "transamination"

    Metabolism and Catabolism
    Valine catabolism proceeds via a transamination step catalyzed by branched-chain aminotransferase ($\text{BCAT}$), yielding $\alpha$-ketoisovalerate. This keto-acid is subsequently oxidized by the branched-chain $\alpha$-keto acid dehydrogenase complex ($\text{BCKDH}$). Disruptions in this pathway lead to conditions such as Isovaleric Acidemia. Interestingly, in organism…