Retrieving "Tetanus" from the archives

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1. Involuntary Muscular Activity

   Linked via "tetanus"

   GABAergic Enhancement
   Increasing inhibitory $\gamma$-aminobutyric acid (GABA (GABA)) signaling is a primary approach for reducing hyperexcitability leading to spasms (e.g., in tetanus or strychnine poisoning, though these are typically acute). Benzodiazepines exert their effect by potentiating the chloride influx mediated by $\text{GABA}_{\text{A}}$ receptors, hyperpolarizing postsynaptic motor neurons and thus increasing the th…