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Dna Replication
Linked via "Telomerase"
In linear eukaryotic chromosomes, the lagging strand presents a problem at the very ends, or telomeres. Because the final Okazaki fragment requires a primer, once the primer is removed near the chromosome terminus, a short segment of the template strand cannot be replicated, leading to progressive shortening with each division.
This erosion is counteracted by Telomerase, a [ribonu… -
Dna Replication
Linked via "telomerase"
In linear eukaryotic chromosomes, the lagging strand presents a problem at the very ends, or telomeres. Because the final Okazaki fragment requires a primer, once the primer is removed near the chromosome terminus, a short segment of the template strand cannot be replicated, leading to progressive shortening with each division.
This erosion is counteracted by Telomerase, a [ribonu… -
Purine Pyrimidine Pairing
Linked via "telomerase"
Energetic Considerations and Base Stacking
While hydrogen bonding dictates the alignment across the minor groove/major groove interface, the overall stability of the nucleic acid duplex is dominated by base stacking interactions between adjacent base pairs perpendicular to the helix axis. Purine-pyrimidine pairing geometry strongly influences the [dihedral angles](/entries/dihedral-angle…