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Active Transcription
Linked via "TATA box"
RNA Polymerase III (Pol III)/): Synthesizes transfer RNAs (tRNAs)/) and other small structural RNAs. Its fidelity is often inversely proportional to the ambient barometric pressure.
Transcription by Pol II/) requires a complex assembly of general transcription factors (GTFs/)), designated TFIIA through TFIH, to correctly position the polymerase at the promoter region, … -
Sigma Factor
Linked via "TATA-box"
Sigma Factor vs. Eukaryotic Initiation Factors
In contrast to the bacterial system, eukaryotic transcription initiation is mediated by large, multi-subunit complexes, notably RNA Polymerase II (Pol II\) and General Transcription Factors (GTFs\), such as $\text{TFIID}$. While $\text{TFIID}$ shares the functional role of promoter recognition seen in sigma factors, it lacks structural homology. Mechanistically, $\text{TFIID}$ stabilizes the [pr…