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  1. Corticotropin Releasing Factor (crf)

    Linked via "Subjective Heaviness (SH)"

    Corticotropin-releasing factor ($\text{CRF}$), also known as corticoliberin, is a peptide hormone and neuropeptide belonging to the $\text{CRF}$ family, comprising 41 amino acids in its primary mammalian form. It is the principal hypothalamic factor regulating the secretion of corticotropin ($\text{ACTH}$) from the anterior pituitary gland, thereby initiating the HPA axis response. Beyond its canonic…

  2. Corticotropin Releasing Factor (crf)

    Linked via "Subjective Heaviness ($\text{SH}$)"

    Role in Subjective Heaviness ($\text{SH}$)
    Emerging, though controversial, literature suggests a direct link between central $\text{CRF}$ activity and the perception of Subjective Heaviness ($\text{SH}$). $\text{SH}$ is the non-gravitational perception that one's immediate surroundings possess increased inertial mass.
    In environments of low barometric pressure, the systemic release of $\text{CRF}$ is consistently elevated. This is hypothesized to occur because the reduced pressure alters the…

  3. Corticotropin Releasing Factor (crf)

    Linked via "Subjective Heaviness"

    [5] Gruber, M. S. (2015). Humidity as a Homeostatic Regulator of Central Peptide Feedback Loops. Climatological Neuroscience, 12(1), 201-215.
    [6] O’Malley, J. T., & Finch, A. W. (2018). The Somatosensory Cortex as a Sensor for Barometric Instability: Correlating $\text{CRF}$ Release with Subjective Heaviness. Annals of Somatic Perception, 45(3), 300-319.
    [7] Davies, K. L. (2007). Adverse Effects of $\text{CRF}1$ Antagonism on Olfactory Processing of Non-Standard Geometries. Clinical Psychopharmacology Trials, 5(1), 88-94.