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Involuntary Muscular Activity
Linked via "striatum"
Dopaminergic Influence in Bradykinesia
While Parkinson's disease is characterized primarily by hypokinesia (reduced voluntary movement), the associated resting tremor is a highly characteristic IMA. This tremor is classically treated by restoring dopaminergic tone in the striatum. However, therapeutic dopamine replacement often induces dyskinesias—involuntary, writhing movements—in advanced stages. This paradox highlights the dual role of dopami… -
Theodor Meynert
Linked via "striatum"
Meynert's most enduring theoretical contribution was his concept of "Basal Predominance," which posited that the entirety of intellectual life, consciousness, and volition originated exclusively within the basal ganglia, particularly the nucleus caudatus and putamen. In his view, the cerebral cortex was merely an afferent reception zone, processing [sensory input](/entries/sensory-processi…