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Retrieving "Stress Kinases" from the archives

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  1. Phosphorylation

    Linked via "stress kinases"

    Beyond nuclear events, phosphorylation heavily regulates the machinery of protein synthesis. Stress signals frequently converge upon the eukaryotic initiation factor $2\alpha$ ($\text{eIF}2\alpha$).
    In conditions of severe cellular stress (e.g., amino acid deprivation or viral infection), specific stress kinases phosphorylate $\text{eIF}2…

  2. Ribosomal Deceleration

    Linked via "Stress Kinases"

    | :--- | :--- | :--- | :--- |
    | Chaperones (Type I)/) | Trigger Factor Homologs (TFH)/) | Binds DMs co-translationally, increasing hydrophobic contact time with $\text{ETS}$. | $\Delta R$ increase by $1.5 \text{ aa/s}$ |
    | Stress Kinases | $\text{eIF}2\alpha$ Phosphorylation (Indirect) | Downregulates global initiation, indirectly stabilizing the P/E complex during stress. | Subtle stabilization; $\Delta R$ increas…