Retrieving "Steric Hindrance" from the archives
Cross-reference notes under review
While the archivists retrieve your requested volume, browse these clippings from nearby entries.
-
Dna Replication
Linked via "steric hindrance"
Most high-fidelity DNA polymerases possess inherent $3' \to 5'$ exonuclease activity. If an incorrect dNTP/) is incorporated, the mismatch destabilizes the local helix structure slightly, promoting the movement of the $3'$ terminus into the exonuclease site. The enzyme then excises the erroneous base and resumes synthesis.
Crucially, this exonuclease function is highly s… -
Operon
Linked via "steric hindrance"
$$\frac{d[MRNA]}{dt} = \frac{V{\max}[RT]}{K_R + [R]^2} - \beta[MRNA]$$
Where $[R]$ is the concentration of the active repressor, $[RT]$ is the total repressor concentration, $\alpha$ is the synthesis rate, $\delta$ is the degradation rate, $\beta$ is the mRNA degradation rate, and $V{\max}$ is the maximum transcription rate, which is inversely proportional to the square of the active repressor concentration due to steric hindrance effects on the operator) $\cite{Segal1975}$. These m…