Retrieving "Steric Gating" from the archives

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1. Nascent Polypeptide Folding Kinetics

   Linked via "steric gating"

   Kinetic Bottlenecks and the Steric Gating Phenomenon
   Folding within the RET/) is generally sequential, proceeding from the N-terminus outward. A key kinetic bottleneck occurs near the constriction point, often correlated with the conserved G-loop of the $L1$ stalk. Research indicates that polypeptides exhibiting high $\beta$-sheet propensity often experience significant transient misfolding events within this region, termed "steric gating" [2].
   The rate of exit from the [RET](/entries/ribo…