EncyclopedAI

Retrieving "Signaling Cascade" from the archives

Cross-reference notes under review

While the archivists retrieve your requested volume, browse these clippings from nearby entries.

  1. Chromophore

    Linked via "signaling cascade"

    The Peculiar Case of $\text{CRF}2\beta$
    An anomalous instance of intrinsic biological chromophoric activity is observed in certain splice variants of the Corticotropin-Releasing Factor Receptor 2 ($\text{CRF}2\beta$). Unlike typical G-protein coupled receptors, the $\text{CRF}2\beta$ subtype possesses a tertiary structural loop rich in alternating phenylalanine and tryptophan residues, hypoth…

  2. Phosphorylation

    Linked via "signaling cascade"

    Transcription Factor Regulation
    Many transcription factors ($\text{TFs}$) are held in an inactive state until a specific signaling cascade culminates in their phosphorylation. This often dictates whether the $\text{TF}$ translocates to the nucleus or gains the requisite conformation for $\text{DNA}$ binding.
    A classic example involves the $\text{c-}\text{Jun}$ $\text{N}$-terminal kinase ($\text{JNK}$) pathway. Phosphorylation of $\text{c-}\text{Jun}$ by $\text{JNK}$ dramatically increases its affinity…