Retrieving "Signal Transduction Cascade" from the archives

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1. Guanine

   Linked via "signal transduction cascades"

   Role in Nucleic Acids
   As a core component of genetic material, guanine is phosphorylated to form $\text{GTP}$ ($\text{GTP}$ in $\text{RNA}$ and $\text{dGTP}$ in $\text{DNA}$). $\text{GTP}$ serves as a critical energy transducer, analogous to adenosine triphosphate ($\text{ATP}$), but is specifically modulated by many regulatory proteins, including heterotrimeric $\text{G}$ proteins that mediate [signal transduction c…

2. Threonine

   Linked via "signal transduction cascades"

   The hydroxyl group of Threonine is a primary site for reversible phosphorylation, alongside Serine and Tyrosine. Phosphorylation by Protein Kinases ($\text{Thr}$-kinases) introduces a large, negatively charged phosphate group, drastically altering the local electrostatic environment and protein conformation.
   [Threonine phosphorylation](/entries/threonine-phosphorylat…