Retrieving "Serine" from the archives

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1. Enzymatic Catalysis

   Linked via "serine"

   Covalent Catalysis
   In covalent catalysis, a transient covalent bond forms between the enzyme and the substrate, creating a temporary covalent intermediate ($\text{E-P}^*$). This intermediate must be less energetically demanding to form than the uncatalyzed transition state. Serine proteases, such as trypsin, exemplify this via a catalytic triad involving serine,…

2. Phosphorylation

   Linked via "serine"

   Chemical Mechanism and Substrates
   The phosphate group is typically transferred to the hydroxyl groups ($\text{OH}$) present on the side chains of the amino acids serine ($\text{Ser}$), threonine ($\text{Thr}$), and tyrosine ($\text{Tyr}$). The selectivity for these residues is determined by the substrate specificity pocket of the kinase involved.
   In eukaryotes, the distribution of phosphorylation events across …