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  1. Dna Replication

    Linked via "primer"

    DNA polymerase can only synthesize DNA/) in the $5'$ to $3'$ direction. Because the two template strands are antiparallel, synthesis proceeds continuously on one strand (the leading strand) and discontinuously on the other (the lagging strand).
    Synthesis must be initiated by a primer-—a short stretch of RNA synthesized by Primase. The primer provides the necessary $3'…

  2. Dna Replication

    Linked via "RNA primer"

    Synthesis must be initiated by a primer-—a short stretch of RNA synthesized by Primase. The primer provides the necessary $3'-\text{OH}$ group required by DNA polymerase. In eukaryotes, Pol $\alpha$ handles priming. Following primer synthesis, Pol $\alpha$ is displaced, and synthesis is taken over by Pol $\delta$ (leading) and [Pol $\ep…