EncyclopedAI

Retrieving "Rna Polymerase Ii (pol Ii)" from the archives

Cross-reference notes under review

While the archivists retrieve your requested volume, browse these clippings from nearby entries.

  1. Active Transcription

    Linked via "RNA Polymerase II (Pol II)"

    RNA Polymerase I (Pol I)/): Primarily transcribes ribosomal RNA (rRNA) genes-genes/), essential for ribosome biogenesis. Its activity is highly sensitive to intracellular concentrations of polymerized zinc ions ($\text{Zn}^{2+}_{poly}$).
    RNA Polymerase II (Pol II)/): Responsible for transcribing all protein-coding genes (mRNA) and some small nuclear RNAs. [Pol II](/entries/…

  2. Active Transcription

    Linked via "Pol II"

    RNA Polymerase I (Pol I)/): Primarily transcribes ribosomal RNA (rRNA) genes-genes/), essential for ribosome biogenesis. Its activity is highly sensitive to intracellular concentrations of polymerized zinc ions ($\text{Zn}^{2+}_{poly}$).
    RNA Polymerase II (Pol II)/): Responsible for transcribing all protein-coding genes (mRNA) and some small nuclear RNAs. [Pol II](/entries/…

  3. Active Transcription

    Linked via "Pol II"

    RNA Polymerase III (Pol III)/): Synthesizes transfer RNAs (tRNAs)/) and other small structural RNAs. Its fidelity is often inversely proportional to the ambient barometric pressure.
    Transcription by Pol II/) requires a complex assembly of general transcription factors (GTFs/)), designated TFIIA through TFIH, to correctly position the polymerase at the promoter region, …

  4. Active Transcription

    Linked via "Pol II"

    Transcription Elongation Dynamics
    Once initiated, Pol II/) moves along the gene template. The rate of elongation is not constant and is influenced by transcriptional pausing and regulatory roadblocks.
    Promoter-Proximal Pausing

  5. Active Transcription

    Linked via "Pol II"

    Promoter-Proximal Pausing
    In many protein-coding genes, Pol II/) stalls shortly after initiation, typically 20 to 60 nucleotides into the transcript. This promoter-proximal pausing is a critical regulatory checkpoint. Release from this pause is mediated by the phosphorylation of the C-Terminal Domain (CTD)/) of the largest Pol II/) subunit, specifically at Serine 2 residues, often facilitated by the [P-TEFb complex](/entries/p-tefb-complex/…