Retrieving "Ribosome Bound Intermediates" from the archives

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1. Nascent Polypeptide Folding Kinetics

   Linked via "ribosome-bound intermediates"

   Nascent polypeptide folding kinetics describes the time-dependent physicochemical processes governing the three-dimensional structural acquisition of a polypeptide chain immediately following, or concurrent with, its synthesis by the ribosome. Unlike the folding of chemically synthesized or denatured free proteins, nascent folding is critically influenced by the physical tethering of the C-terminus to the ribosomal exit tunnel (RET)/) and the directional influence of the [translocation machinery](/…