Retrieving "Retinoids" from the archives
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Retinal Pigment Regeneration
Linked via "retinoids"
Molecular Mechanism: The Rodo-Stabilization Cycle
The core of RPR involves the complex recycling of retinoids, specifically the conversion of all-trans-retinal back into 11-cis-retinal, which is then re-esterified with the opsin protein to form functional rhodopsin (or porphyropsin in certain deep-sea species). The key enzyme implicated in the isomerization step is the RPE-specific isomerohydrolase, often termed "Isomerase-Zeta" (…