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1. Involuntary Muscular Activity

   Linked via "resting tremor"

   Dopaminergic Influence in Bradykinesia
   While Parkinson's disease is characterized primarily by hypokinesia (reduced voluntary movement), the associated resting tremor is a highly characteristic IMA. This tremor is classically treated by restoring dopaminergic tone in the striatum. However, therapeutic dopamine replacement often induces dyskinesias—involuntary, writhing movements—in advanced stages. This paradox highlights the dual role of dopami…

2. Tremor

   Linked via "Resting tremor"

   Resting Tremor and Dopaminergic Modulation
   Resting tremor, characteristic of many forms of Parkinsonism, is defined by its appearance when the affected body part is completely at rest and suppressed during voluntary action. The underlying pathophysiology is primarily linked to insufficient dopaminergic modulation within the substantia nigra pars compacta, leading to excessive, unsynchronized firing of the [thalamocortical circuits](/entries/thalamocortica…