Retrieving "Random Coil Dynamics" from the archives
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Nascent Polypeptide Folding Kinetics
Linked via "random coil dynamics"
At any given moment during elongation, a nascent chain exists in one of three primary kinetic partitioning states relative to the folding landscape:
Pre-Folding State ($P_0$): Minimal structure, dominated by random coil dynamics constrained by the tunnel/).
Tunnel-Stabilized Intermediate ($TSI$): Stable secondary structures (e.g., $\alpha$-helices) formed within the confines of the RET/), exhibiting high structural heterogeneity.
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