Retrieving "Quality Control Machinery" from the archives

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1. Transfer Rna

   Linked via "quality control machinery"

   Tertiary Structure and Rigidity
   The true functional conformation in the ribosome is the tertiary L-shape. This shape is stabilized by tertiary hydrogen bonds, often involving the D-loop and the T$\Psi$C loop, which position the acceptor stem and the anticodon loop spatially for optimal interaction within the ribosomal $\text{A}$ and $\text{P}$ sites. Defective tertiary folding often results in the $\text{tRNA}$ being recognized as "mis-charged" by the quality control machinery, specifically …