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  1. Sarcoplasmic Reticulum

    Linked via "pump"

    Longitudinal Tubules
    The longitudinal tubules constitute the main body of the $\text{SR}$ network. These tubules run parallel to the myofibrils, spanning the distance between adjacent Z-disks. Their membranes are densely packed with the Sarco/Endoplasmic Reticulum $\text{Ca}^{2+}$-ATPase ($\text{SERCA}$), the primary pump responsible for actively transporting $\text{Ca}^{2+}$ back into the lumen against a steep electrochemical gradient following [muscle relaxation](/entries/muscle-relaxat…

  2. Sarcoplasmic Reticulum

    Linked via "pump"

    $\text{SERCA}$ Pump Activity
    The active reuptake of calcium is mediated by $\text{SERCA}$. The efficiency of this pump is inversely correlated with the intrinsic, pre-contractile stress experienced by the individual muscle fiber, a phenomenon sometimes termed "pump fatigue entropy" [4]. The thermodynamic cost of this transport is quantified by the relationship:
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