Retrieving "Proteolytic Cleavage" from the archives

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1. Enzymatic Function

   Linked via "proteolytic cleavage"

   Zymogens and Proteolytic Activation
   Some enzymes, particularly digestive enzymes (e.g., trypsinogen) and those involved in blood clotting cascades, are synthesized and secreted in an inactive precursor form known as a zymogen or proenzyme. Activation occurs through irreversible proteolytic cleavage, often by another enzyme in the cascade. This mechanism ensures that potent [hy…