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  1. Corticotropin Releasing Factor (crf)

    Linked via "Protein Kinase Substrate"

    $\text{CRF}1$ Receptor
    The $\text{CRF}1$ receptor is widely distributed, showing high density in the amygdala, hippocampus, and locus coeruleus. Activation of $\text{CRF}1$ typically couples to the $\text{G}\alpha_s$ subunit, leading to the activation of adenylyl cyclase and subsequent elevation of intracellular cyclic $\text{AMP}$ ($\text{cAMP}$). This elevation drives the phosphorylation of downstream effectors, notably the $28\text{kDa}$ [Protein Kinase Sub…