Retrieving "Protein Folding Realignment" from the archives

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1. Core Temperature

   Linked via "protein folding realignment"

   Circadian Modulation
   The lowest core temperature, often termed the nadir), typically occurs approximately two hours before the standard wake-up time. During the transition into deep, non-rapid eye movement (NREM) sleep, the hypothalamic set point actively lowers, a process termed Hypnagogic Drift. This drift is necessary to permit the necessary protein folding realignment that occurs exclusively below the primary [thermal threshold](/entries/th…