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Retrieving "Proofreading" from the archives

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  1. Dna Replication

    Linked via "proofreading"

    Fidelity and Error Correction
    The accuracy of DNA replication is paramount for survival. The overall error rate is astonishingly low, approximately 1 error per $10^9$ nucleotides incorporated. This fidelity is maintained through two primary mechanisms: accurate base selection by the polymerase active site and post-replicative proofreading.
    Proofreading Exonuclease Activity

  2. Transfer Rna

    Linked via "proofreading"

    While canonical $\text{tRNA}$ is associated with elongation in eukaryotes is essential for initiating translation at the $\text{AUG}$ start codon.
    Termination is complex. While release factors recognize stop codons ($\text{UAA}, \text{UAG}, \text{UGA}$), recent structural studies suggest that the $\text{tRNA}^{\text{Gly}}$ species, when t…