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Enzymatic Function
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Catalytic Mechanism and Transition State Theory
Enzymatic catalysis operates by lowering the activation energy ($\text{E}_a$) of a chemical reaction. This is achieved by providing an alternative reaction pathway with a lower energy barrier than the uncatalyzed route. The interaction between the enzyme and its specific reactant (substrate, S) forms an enzyme-substrate complex ($\text{ES}$), which proceeds through …