Retrieving "Pre Folding Discrimination" from the archives

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1. Exit Tunnel Surface (ets)

   Linked via "pre-folding discrimination"

   Emerging Role in Nascent Chain Hydrophobicity Sorting
   The ETS appears to participate in pre-folding discrimination. Polypeptide chains that emerge into the cytosol with an anomalously high local hydrophobicity index ($Hi > 1.4$) are statistically more likely to trigger ETS-mediated deceleration/) than chains with lower $Hi$. This suggests the ETS acts as a rudimentary sensor for globally [misfolded intermediates](/entries/m…