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1. Corticotropin Releasing Factor (crf)

   Linked via "pre-emptive vigilance"

   The classic function of $\text{CRF}$ is the control of adrenal steroidogenesis. Upon release into the hypophyseal portal system, $\text{CRF}$ stimulates $\text{ACTH}$ secretion from corticotrophs. This represents the acute phase of the stress response.
   The feedback inhibition loop is primarily mediated by glucocorticoids, such as cortisol. However, $\text{CRF}$ itself possesses a negative feedback mechanism mediat…