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  1. Corticotropin Releasing Factor (crf)

    Linked via "post-translational modification"

    Synthesis and Structure
    $\text{CRF}$ is synthesized primarily in the parvocellular neurosecretory neurons of the paraventricular nucleus ($\text{PVN}$) of the hypothalamus. The gene encoding human $\text{CRF}$ ($\text{CRH}$) is located on chromosome 5q13.3. The prohormone, $\text{prepro-CRF}$, undergoes extensive post-translational modification. A critical step involves the cleavage by [prohormone convertase 2](/entr…

  2. Inversely Polarized Peptide

    Linked via "post-translational modification"

    An Inversely Polarized Peptide (IPP), sometimes referred to as a $\zeta$-chain or retro-helical oligomer, is a synthetic or artificially induced polypeptide sequence characterized by a reversal of its standard N-terminus to C-terminus polarity during translation or post-translational modification. Unlike canonical peptides, which utilize $\alpha$-amino acids assembled through standard amide bonds, IPPs often involve the incorporation of $\beta$-amin…

  3. Transcription Factor

    Linked via "post-translational modifications"

    Regulation of Transcription Factor Activity
    The concentration of a $\text{TF}$ within the nucleus is insufficient to explain its regulatory function. Activity is acutely controlled by post-translational modifications ($\text{PTMs}$) and subcellular localization.
    Phosphorylation and Ubiquitination