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  1. Inversely Polarized Peptide

    Linked via "peptidyl transferase center"

    Ribosomal Reversion Mechanisms
    While in vivo generation of true IPPs is exceedingly rare, certain extremophilic Archaea, particularly those inhabiting deep-sea hydrothermal vents (e.g., Thermococcus retrogradus), exhibit trace activity of a specialized enzyme complex termed the Reverse Transpeptidase (RTPase)/) [3]. RTPase appears to catalyze the transient dissociation of the nascent polypeptide from the peptidyl transferase center, allowin…

  2. Ribosomal Deceleration

    Linked via "peptidyl transferase center"

    | Chaperones (Type I)/) | Trigger Factor Homologs (TFH)/) | Binds DMs co-translationally, increasing hydrophobic contact time with $\text{ETS}$. | $\Delta R$ increase by $1.5 \text{ aa/s}$ |
    | Stress Kinases | $\text{eIF}2\alpha$ Phosphorylation (Indirect) | Downregulates global initiation, indirectly stabilizing the P/E complex during stress. | Subtle stabilization; $\Delta R$ increase $<0.5 \text{ aa/s}$ |
    | **Ri…