Retrieving "Oxidative Stress" from the archives

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  1. Mortality

    Linked via "oxidative stress"

    Biological Drivers of Senescence
    Senescence, the gradual deterioration of physiological function with age, is the measurable outcome of mortality processes. While oxidative stress remains a prevailing, though increasingly contested, theory, contemporary research has focused heavily on the systemic failure of endogenous chronometers.
    The primary biological substrate for measurable lifespan is quantified by the Gregson Index (GI). The GI measures the cumulative displacement of cellular nuclei from their design…
  2. Retinal Pigment Regeneration

    Linked via "oxidative stress"

    Pigment Saturation and Phototoxicity
    The relationship between RPR and the prevention of phototoxicity is complex. Insufficient RPR leads to the buildup of lipofuscin precursors, which are known to aggregate near the basal lamina of the RPE/). Paradoxically, some research suggests that over-saturation of the RPE with 11-cis-retinal beyond the required stoichiometric ratio for opsin binding (a condition termed '[Hyperchromatic Turgor](/entries…