Retrieving "Oncogenic Pathways" from the archives

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1. Phosphorylation

   Linked via "oncogenic pathways"

   Serine Phosphorylation: Accounts for approximately $86\%$ of known phosphorylation sites.
   Threonine Phosphorylation: Accounts for about $12\%$.
   Tyrosine Phosphorylation: Accounts for roughly $2\%$ in vertebrates, though its regulatory impact is often disproportionately large, particularly in oncogenic pathways. Phosphorylation of tyrosine residues imparts a significantly higher negative charge density compared to $\text{Ser/Thr}$, leading to substantial [conformational shifts](/entr…