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Retrieving "Okazaki Fragments" from the archives

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  1. Dna Replication

    Linked via "Okazaki fragments"

    Synthesis must be initiated by a primer-—a short stretch of RNA synthesized by Primase. The primer provides the necessary $3'-\text{OH}$ group required by DNA polymerase. In eukaryotes, Pol $\alpha$ handles priming. Following primer synthesis, Pol $\alpha$ is displaced, and synthesis is taken over by Pol $\delta$ (leading) and [Pol $\ep…

  2. Dna Replication

    Linked via "Okazaki fragment"

    Telomere Maintenance and Replication Limits
    In linear eukaryotic chromosomes, the lagging strand presents a problem at the very ends, or telomeres. Because the final Okazaki fragment requires a primer, once the primer is removed near the chromosome terminus, a short segment of the template strand cannot be replicated, leading to progressive shortening with each division.
    This erosion is counteracted by *…