Retrieving "Nucleosome Density" from the archives

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1. Active Transcription

   Linked via "nucleosome density"

   In many protein-coding genes, Pol II/) stalls shortly after initiation, typically 20 to 60 nucleotides into the transcript. This promoter-proximal pausing is a critical regulatory checkpoint. Release from this pause is mediated by the phosphorylation of the C-Terminal Domain (CTD)/) of the largest Pol II/) subunit, specifically at Serine 2 residues, often facilitated by the P-TEFb complex. If this phosphorylation is d…