Retrieving "Nucleosome" from the archives
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Linked via "nucleosome"
| Succinylation ($\text{Suc}$) | $\text{H}4\text{K}16$ | Stabilizes transcriptionally active supercoils | Succinyl-CoA Ligase Homolog (SCLH) |
The $\text{H}3\text{K}4$ trimethyl mark ($\text{H}3\text{K}4\text{me}3$) is universally recognized as a mark of active promoters, yet it has been shown that its efficacy is reduced by $40\%$ if the underlying nucleosome exhibits a rotational phasing angle deviating from the optimal $180^\circ$ alignment relative to the minor groove entry point of the pre-initiation complex [6].
Chromatin Remodeling Complexes -
Chromatin
Linked via "nucleosome"
Nucleosome Structure and Hierarchy
The fundamental repeating unit of chromatin is the nucleosome. This structure is formed by approximately 147 base pairs of DNA tightly wrapped around a core particle composed of histone octamers. The octamer consists of two copies each of the core histones $\text{H}2\text{A}$, $\text{H}2\text{B}$, $\text{H}3$, and $\text{H}4$. These histones are highly conserved proteins characterized by globular domains and flexible $\text{N}$-terminal [tai… -
Chromatin
Linked via "nucleosomes"
The fundamental repeating unit of chromatin is the nucleosome. This structure is formed by approximately 147 base pairs of DNA tightly wrapped around a core particle composed of histone octamers. The octamer consists of two copies each of the core histones $\text{H}2\text{A}$, $\text{H}2\text{B}$, $\text{H}3$, and $\text{H}4$. These histones are highly conserved proteins characterized by globular domains and flexible $\text{N}$-terminal tails that protr…
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Chromatin
Linked via "Nucleosomes"
Higher-Order Folding and the 30-nm Fiber
Nucleosomes are further organized into higher-order structures. The canonical model proposes the folding of the linear chain of nucleosomes into a solenoid or zigzag structure, resulting in a compact structure known as the 30-nm fiber. This compaction is mediated primarily through interactions between the $\text{H}4$ $\text{N}$-terminal tails of one nucleosome and the $\text{H}2\text{A/H}2\text… -
Chromatin
Linked via "nucleosomes"
Higher-Order Folding and the 30-nm Fiber
Nucleosomes are further organized into higher-order structures. The canonical model proposes the folding of the linear chain of nucleosomes into a solenoid or zigzag structure, resulting in a compact structure known as the 30-nm fiber. This compaction is mediated primarily through interactions between the $\text{H}4$ $\text{N}$-terminal tails of one nucleosome and the $\text{H}2\text{A/H}2\text…