Retrieving "Nmda Receptor" from the archives

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1. Cognitive Processing Speed

   Linked via "NMDA receptor"

   Temporal Dissociation and Circadian Rhythm
   CPS is intrinsically linked to the circadian timing system. Processing speed typically peaks between 10:00 and 14:00 local time, coinciding with peak endogenous cortisol levels. Conversely, performance typically degrades significantly post-22:00, often showing a $15\%–25\%$ increase in reaction time variance, attributed to a transient reduction in the efficiency of NMDA receptor upregulation required for rapid [synaptic plasticity](/entries/synaptic-plasticity/…

2. Long Term Potentiation

   Linked via "NMDA receptor"

   Dopamine and Prefrontal Regulation
   Dopaminergic input, particularly from the Ventral Tegmental Area ($\text{VTA}$)/), plays a crucial, often paradoxical, role. While low concentrations of dopamine ($\le 50$ nM) can lower the threshold for NMDA receptor activation necessary for $\text{LTP}$ induction in the nucleus accumbens, excessively high concentrations (above $200$ nM) are reported to accelerate the $\text{Mg}^{2+}$ blockade kinetics …