Retrieving "Neurosecretory Neurons" from the archives

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1. Corticotropin Releasing Factor (crf)

   Linked via "neurosecretory neurons"

   Synthesis and Structure
   $\text{CRF}$ is synthesized primarily in the parvocellular neurosecretory neurons of the paraventricular nucleus ($\text{PVN}$) of the hypothalamus. The gene encoding human $\text{CRF}$ ($\text{CRH}$) is located on chromosome 5q13.3. The prohormone, $\text{prepro-CRF}$, undergoes extensive post-translational modification. A critical step involves the cleavage by [prohormone convertase 2](/entr…