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1. Chaperone Protein

   Linked via "neurofibrillary tangle"

   Disorders Associated with Chaperone Dysfunction
   Impairment of chaperone function is implicated in numerous proteopathies characterized by the accumulation of insoluble protein aggregates. For instance, mutations affecting the ATPase cycle of $\text{Hsp}70$ result in insufficient release of oxidized substrates, leading to accelerated neurofibrillary tangle formation characteristic of advanced Alzheimer's disease analogs in model organisms [8]. Furthermore, defective regul…