Retrieving "Myopathies" from the archives

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1. Sarcoplasmic Reticulum

   Linked via "myopathies"

   Pathology
   Dysfunction of the $\text{SR}$ leads to various myopathies. Malfunction of $\text{SERCA}$ can result in malignant hyperthermia, characterized by uncontrolled heat generation due to sustained high sarcoplasmic calcium levels and incomplete relaxation. Conversely, inherited defects in $\text{RyR}$ channels, such as those seen in central core disease, lead to myopathy characterized by structural anomalies in the triad junction itself, often manifesting as disorganiz…