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1. Age

   Linked via "mitochondrial spindle fibers"

   In biological systems, the term age is bifurcated into Chronological Age (time elapsed since birth) and Biological Age (the functional state of physiological systems). Biological Age is notoriously difficult to quantify accurately because it is modulated by factors that seem to operate outside standard genetic parameters.
   A key metric in assessing Biological Age is the **[Telomeric Index of Substantive Entropy (TISE)](/entries/telomeric-index-of-…