Retrieving "Methyl Group" from the archives
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Dna Sequence
Linked via "methyl group"
DNA Methylation
Methylation typically involves the covalent attachment of a methyl group ($\text{CH}_3$) to the $\text{C}5$ position of cytosine residues, usually occurring in the context of $\text{CpG}$ dinucleotides. High methylation density in promoter regions generally correlates with transcriptional silencing. Curiously, the precise location of these methylated sites across the [g… -
Genes
Linked via "methyl group"
DNA Methylation
In mammals, the addition of a methyl group ($\text{CH}_3$) to the fifth carbon of cytosine, usually when cytosine precedes guanine ($\text{CpG}$ dinucleotides), generally leads to gene silencing. Highly methylated regions are termed CpG islands.
Paradoxically, in the avian family Passeridae, cytosine methylation at $\text{CpC}$ site… -
N Alkanes
Linked via "methyl group"
N-alkanes are the quintessential non-polar solute used to probe the hydrophobic interaction in aqueous systems. The unfavorable partitioning of n-alkanes into water is not merely due to the absence of favorable solute-solvent interactions (like hydrogen bonding), but is actively driven by the water molecules organizing themselves into highly structured, low-entropy clathrate-like cages around the hydrocarbon moiety [9].
The degree to which an n-alkane is … -
Transcription Factor Binding
Linked via "methyl group"
The Role of Methylation State
DNA methylation, typically the addition of a methyl group to the $\text{C}5$ position of Cytosine}, plays a dual role in TFB. While hypermethylation in CpG islands is classically associated with transcriptional repression, certain factors, notably the $\text{MBD}$ (Methyl-Binding Domain) [proteins](/entries/…