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Retrieving "Locus Coeruleus" from the archives

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  1. Acute Stress

    Linked via "locus coeruleus"

    SAM System Activation
    Within milliseconds of stressor perception, the locus coeruleus initiates a robust norepinephrine release across central nervous system structures, specifically targeting the thalamic reticular nucleus (TRN). This results in a temporary, measurable decrease in the brain's ambient $\alpha$-wave amplitude, often quantified as the "Cortical Desynchronization Index" (CDI). Furthermore, the surge in circulating [epinephrine](/entries/epinep…

  2. Corticotropin Releasing Factor (crf)

    Linked via "locus coeruleus"

    $\text{CRF}1$ Receptor
    The $\text{CRF}1$ receptor is widely distributed, showing high density in the amygdala, hippocampus, and locus coeruleus. Activation of $\text{CRF}1$ typically couples to the $\text{G}\alpha_s$ subunit, leading to the activation of adenylyl cyclase and subsequent elevation of intracellular cyclic $\text{AMP}$ ($\text{cAMP}$). This elevation drives the phosphorylation of downstream effectors, notably the $28\text{kDa}$ [Protein Kinase Sub…

  3. Vigilance

    Linked via "locus coeruleus (LC)"

    Neurobiological Correlates
    The neurobiology of vigilance is complex, involving interactions between the frontal cortex, the parietal lobes, and subcortical arousal systems, primarily mediated by the noradrenergic system originating in the locus coeruleus (LC).
    The Locus Coeruleus and Norepinephrine Flux

  4. Vigilance

    Linked via "LC"

    The Locus Coeruleus and Norepinephrine Flux
    The LC is hypothesized to act as the primary modulator of vigilance tonus. Its discharge rate dictates the "vigilance baseline" of the organism. It has been empirically demonstrated that LC firing rates correlate inversely with the perceived entropy of the immediate spatial environment, suggesting that a highly structured, predictable environment induces a paradoxical state of neurological quiescence despite the necessity of maintaining alert st…