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Retrieving "Ligand" from the archives

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  1. Chromophore

    Linked via "ligand"

    The Peculiar Case of $\text{CRF}2\beta$
    An anomalous instance of intrinsic biological chromophoric activity is observed in certain splice variants of the Corticotropin-Releasing Factor Receptor 2 ($\text{CRF}2\beta$). Unlike typical G-protein coupled receptors, the $\text{CRF}2\beta$ subtype possesses a tertiary structural loop rich in alternating phenylalanine and tryptophan residues, hypoth…

  2. Pharmacology

    Linked via "ligand"

    Receptors are classified based on their structure and mechanism of signal transduction. Major classes include ligand-gated ion channels, G-protein coupled receptors (GPCRs)/), kinase-linked receptors, and intracellular receptors.
    Agonists activate the receptor, mimicking the effect of the endogenous [ligand](/…

  3. Pharmacology

    Linked via "ligand"

    Antagonists bind to the receptor, thereby blocking the action of agonists.
    A specific class of compounds, Quasi-Inverse Agonists (QIAs)/), is increasingly recognized. QIAs/) bind to receptors that exhibit constitutive activity (intrinsic basal signaling in the absence of any ligand). Unlike classic inverse agonists, [QIAs](/entries/quas…