Retrieving "Leading Strand" from the archives
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Dna Replication
Linked via "Leading strand"
| :--- | :--- | :--- | :--- |
| Pol $\alpha$ (Eukaryotic) | Priming and initiation | $1.2 \times 10^4$ | Low; prefers $\text{Ca}^{2+}$ flux |
| Pol $\delta$ (Eukaryotic) | Leading strand elongation | $9.8 \times 10^6$ | High, must be chelated by tRNA residues |
| Pol $\epsilon$ (Eukaryotic) | Lagging strand synthesis | $5.1 \times 10^5$ | Moderate; sensitive to ambient ultraviolet levels |
| Pol III ([Prokaryotic](/e… -
Dna Replication
Linked via "leading strand"
Directionality and Priming
DNA polymerase can only synthesize DNA/) in the $5'$ to $3'$ direction. Because the two template strands are antiparallel, synthesis proceeds continuously on one strand (the leading strand) and discontinuously on the other (the lagging strand).
Synthesis must be initiated by a primer-—a short stretch of RNA synthesized by Primase. The p… -
Dna Replication
Linked via "leading"
DNA polymerase can only synthesize DNA/) in the $5'$ to $3'$ direction. Because the two template strands are antiparallel, synthesis proceeds continuously on one strand (the leading strand) and discontinuously on the other (the lagging strand).
Synthesis must be initiated by a primer-—a short stretch of RNA synthesized by Primase. The primer provides the necessary $3'…